Publications

Publications & Posters

2024
  • Publication
  • Pharmaceutics

Safety of Repeated Administration of Xenogeneic Human Apoptotic State (Allocetra-OTS) in Sprague Dawley Rats

Chen Ankri, et al

2023
  • Publication
  • Frontiers in Immunology

Apoptotic cells for treatment of acute respiratory distress syndrome associated with COVID-19

Peter Vernon van Heerden, Avraham Abutbul, Ahmad Naama, Shlomo Maayan, Nassar Makram, Akiva Nachshon, Kamal abu Jabal, Oren Hershkovitz, Lior Binder, Yehudit Shabat, Barak Reicher, and Dror Mevorach, Frontiers in Immunology.

2023
  • Poster
  • ASCO 2023. Boston, IL USA

Enlivex therapeutics macrophage reprogramming as a paradigm shift in the treatment of life-threatening indications with unmet medical need

Hershkovitz, et al

2023
  • Poster
  • ISCT 2023. Paris, France

Development of a frozen formulation of Allocetra-OTS, an innovative macrophage reprogramming cell-based therapy

Amor-Baroukh, et al

2023
  • Poster
  • ISCT 2023. Paris, France

In-vitro biological activity characterization and cell-based potency assay development for Allocetra-OTS,a novel macrophage reprogramming cell therapy developed for the treatment of sepsis

Ankri, et al

2022
  • Poster
  • ASCO 2022. Boston, MA USA

Allocetra-OTS, an Early Apoptotic Cellular Therapy Synergize with Immune Check Point Inhibitors and Chimeric Antigen Receptor (CAR) T Cell Therapy Against Peritoneal Solid Tumor

Mevorach, et al

2022
  • Poster
  • ISCT 2022. San Francisco, CA USA

Allocetra-OTS, an Early Apoptotic Cellular Therapy Synergize with Chimeric Antigen Receptor (CAR) T Cell Therapy or Immune Check Point Inhibitor Against Peritoneal Solid Tumor

Mevorach, et al

2022
  • Poster
  • ISCT 2022. San Francisco, CA USA

Treatment with Allocetra–OTS in 21 severely/critically ill patients with COVID-19, leading to swift discharge and cytokine storm resolution

Van Heerdan, et al

2021
  • Publication
  • Frontiers in Immunology

Apoptotic Cells for Therapeutic Use in Cytokine Storm Associated With Sepsis– A Phase Ib Clinical Trial

Peter Vernon van Heerden, Avraham Abutbul, Sigal Sviri, Eitan Zlotnick, Ahmad Nama, Sebastian Zimro, Raja el-Amore, Yehudit Shabat, Barak Reicher, Batla Falah and Dror Mevorach

2020
  • Publication
  • Cell Death & Disease

Apoptotic cell therapy for cytokine storm associated with acute severe sepsis

Netanel Karbian, Avraham Abutbul, Raja el-Amore, Ran Eliaz, Ronen Beeri, Barak Reicher and Dror Mevorach

2019
  • Publication
  • Joint IIS-ISCR Special Conference

Synergism between human apoptotic cell infusion (Allocetra-OTS) and human chimeric antigen receptor (CAR)- T therapy in fighting solid human tumor in SCID Bg mice

Dror Mevorach

2019
  • Publication
  • Frontiers in Immunology

The Remarkable Plasticity of Macrophages: A Chance to Fight Cancer

Nadège Bercovici, Marion V. Guérin, Alain Trautmann and Emmanuel Donnadieu

2017
  • Publication
  • Frontiers in Immunology

Apoptotic Cells induced Signaling for immune Homeostasis in Macrophages and Dendritic Cells

Uriel Trahtemberg and Dror Mevorach

2016
  • Publication
  • PLOS ONE

Identification and Characterization of Two Human Monocyte-Derived Dendritic Cell Subpopulations with Different Functions in Dying Cell Clearance and Different Patterns of Cell Death

Trahtemberg U, Grau A, Tabib A, Atallah M, Krispin A, Mevorach D.

2015
  • Publication
  • PLOS ONE

Apoptotic Cells Induce NF-κB and Inflammasome Negative Signaling

Amir Grau, Adi Tabib, Inna Grau, Inna Reiner, Dror Mevorach

2014
  • Publication
  • Nature reviews

Apoptotic cell clearance: basic biology and therapeutic potential

Ivan K. H. Poon, Christopher D. Lucas, Adriano G. Rossi and Kodi S. Ravichandran

2014
  • Publication
  • Biology of Blood and Marrow Transplantation

Single Infusion of Donor Mononuclear Early Apoptotic Cells as Prophylaxis for Graft-versus-Host Disease in Myeloablative HLA-Matched Allogeneic Bone Marrow Transplantation: A Phase I/IIa Clinical Trial

Dror Mevorach

2010
  • Publication
  • Annals of the New York Academy of Sciences

What do we mean when we write “senescence,” “apoptosis,” “necrosis,” or “clearance of dying cells”?

Mevorach D, Trahtemberg U, Krispin A, Attalah M, Zazoun J, Tabib A, Grau A, Verbovetski-Reiner I.

2010
  • Publication
  • The New York Academy of Sciences

Role of class A human thrombospondins in the clearance of dying cells and tolerance induction

Tabib A, Krispin A, Mevorach D.

2010
  • Publication
  • Apoptosis

Clearance of dying cells and systemic lupus erythematosus: the role of C1q and the complement system

Mevorach D.

2010
  • Publication
  • European Journal of Immunology

iC3b-opsonized apoptotic cells mediate a distinct anti-inflammatory response and transcriptional NF-kB-dependent blockade

Gil Amarilyo, Dror Mevorach, et al

2007
  • Publication
  • Human Immunology

Apoptotic cells inhibit LPS-induced cytokine and chemokine production and IFN responses in macrophages

Tassiulas I, Park-Min KH, Hu Y, Kellerman L, Mevorach D, Ivashkiv LB.

2006
  • Publication
  • Blood

Apoptotic cell thrombospondin-1 and heparin-binding domain lead to dendritic-cell phagocytic and tolerizing states

Krispin A, Bledi Y, Atallah M, Trahtemberg U, Verbovetski I, Nahari E, Zelig O, Linial M, Mevorach D.

2002
  • Publication
  • The Journal of Experimental Medicine

Opsonization of apoptotic cells by autologous iC3b facilitates clearance by immature dendritic cells, down-regulates DR and CD86, and up-regulates CC chemokine receptor 7

Verbovetski I, Bychkov H, Trahtemberg U, Shapira I, Hareuveni M, Ben-Tal O, Kutikov I, Gill O, Mevorach D.