Indication Global
Market Size		 Pre
Clinical		 Phase
Ib		 Phase
IIb		 Potential Support for EU Conditional
Marketing Approval
Submission		 Post EU
Marketing
US Phase 3
Organ failure associated with Sepsis $33B   Completed Multi-country Phase
II ongoing		 Top-line data Phase II
Q3 2023		  
               
Advanced-stage soild tumors with
peritoneal metastases in
combination with chemotherapy		 $4B   Phase I/II
ongoing		      
               
Advanced-stage soild tumors with
peritoneal metastases stand-alone,
+ in combination with anti-PD1		 $4B   Phase I/II
ongoing		      
               

Recent Publications

2021| Apoptotic Cells for Therapeutic Use in Cytokine Storm Associated With Sepsis– A Phase Ib Clinical Trial, Peter Vernon van Heerden, Avraham Abutbul, Sigal Sviri, Eitan Zlotnick, Ahmad Nama, Sebastian Zimro, Raja el-Amore, Yehudit Shabat, Barak Reicher, Batla Falah and Dror Mevorach, Frontiers in Immunology

2019 | The Remarkable Plasticity of Macrophages: A Chance to Fight Cancer, Nadège Bercovici, Marion V. Guérin, Alain Trautmann and Emmanuel Donnadieu, Frontiers in Immunology

2019 | Synergism between human apoptotic cell infusion (Allocetra-OTS) and human chimeric antigen receptor (CAR)- T therapy in fighting solid human tumor in SCID Bg mice, Dror Mevorach, Joint IIS-ISCR Special Conference

2017 | Apoptotic Cells induced Signaling for immune Homeostasis in Macrophages and Dendritic Cells,
Uriel Trahtemberg and Dror Mevorach, frontier in immunology

2014 | Apoptotic cell clearance: basic biology and therapeutic potential,
Ivan K.H. Poon, Christopher D. Lucas, Adriano G. Rossi and Kodi S. Ravichandran,Nature reviews

2014 | Single Infusion of Donor Mononuclear Early Apoptotic Cells as Prophylaxis for Graft-versus-Host Disease in Myeloablative HLA-Matched Allogeneic Bone Marrow Transplantation: A Phase I/IIa Clinical Trial,
Dror Mevorach, Biology of Blood and Marrow Transplantation

2010 | iC3b-opsonized apoptotic cells mediate a distinct anti-inflammatory response and transcriptional NF-kB-dependent blockade,
Gil Amarilyo, Dror Mevorach, et al., European Journal of Immunology

Allocetra MOA

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